Background: Colorectal cancer is the major cause of cancer mortality, despite development of therapeutic\nstrategies. The novel marker tumor necrosis factor receptor-associated protein 1 (TRAP1) is a mitochondrial heat\nshock protein that has been related to drug resistance and protection from apoptosis in colorectal cancer. This\nstudy aims to delineate the clinicopathologic significance of TRAP1 expression in colorectal cancer.\nMethods: Seven-hundred and fourteen FFPE tissues were collected from colorectal cancer patients who underwent\nsurgery from February 2002 to July 2011 at Dong-A University Medical Center, Busan, South Korea. We performed\nTRAP1 immunohistochemistry using tissue microarray, and divided into two groups, TRAP1 high expression group\nand low expression group. Statistical analysis was utilized to evaluate the association of TRAP1 with\nclinicopathologic characteristics and disease-specific survival of patients.\nResults: High TRAP1 expression was observed in 564 cases (79%) and low expression was 150 cases (21%). TRAP1\nexpression was significantly increased in colorectal cancer with advanced pathologic T-stage compared with that in\nearly T-stage (p = 0.008). By univariate survival analysis, high TRAP1 expression was significantly associated with worse\ndisease-specific survival (p = 0.01). But, TRAP1 expression was marginally associated with lymph node involvement and\ntumor differentiation (p = 0.085, p = 0.082, respectively). Multivariate analysis indicated that TRAP1 [removed]hazard\nratio, 1.947; 95% CI, 1.270 to 2.984; p = 0.002), and pathologic T stage (hazard ratio, 3.190; 95% CI, 1.275 to 7.983; p = 0.\n013) were independent prognostic factors for colorectal adenocarcinomas.\nConclusions: Here, we found that overexpression of TRAP1 might contribute to tumor cell local invasion of colorectal\ncancer. The association between TRAP1 overexpression and worse disease-specific survival also suggested that TRAP1\nprotein expression might have oncogenic role. Consequently, our data demonstrated that TRAP1 expression was a\ngood prognostic biomarker for depth of invasion and disease-specific survival in colorectal cancer.
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